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. 2021 Dec 21;14:57. doi: 10.1186/s13072-021-00431-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Nuclear accumulation of histone lactylation and histone acetylation in mouse oocytes and pre-implantation embryos. a–e Histone lactylation and histone acetylation were detected in mouse oocytes and pre-implantation embryos. Specific antibodies were used to detect the pan histone lactylation (a), H3K23la (b), H3K23ac (c), H3K18la (d), H3K18ac (e) in mouse oocytes at the germinal vesicle (GV) and metaphase II (MII) stages, as well as pre-implantation embryos at the zygote (zygote), 2-cell (2-cell), 4-cell (4-cell), morula (Morula) and blastocyst (Blast) stages. Pan histone lactylation, H3K23la and H3K23ac were shown in green. H3K18la and H3K18ac were shown in red. The DNA was stained with DAPI (Blue). More than 9 embryos were examined in each stage of each condition. Scale bars: 20 μm