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. Author manuscript; available in PMC: 2022 May 11.
Published in final edited form as: Circulation. 2021 Apr 1;143(19):1894–1911. doi: 10.1161/CIRCULATIONAHA.120.048698

Figure 1. Cardiac arrhythmias in TAZ CKO mice.

Figure 1.

Male control (TazFL/Y) or cardiac-specific mutant mice (CKO, Myh6-Cre; TazFL/Y) underwent intracardiac EP study at 6 weeks of age. Studies and analyses were performed blinded to genotype. A. Schematic of electrophysiology study protocol. B. Fraction of mice with arrhythmia. Numbers indicate sample sizes. Permutation test. C. Classification of types of arrhythmia within each genotype. D. Representative surface electrocardiograms demonstrating types of arrhythmias observed in CKO. Filled and open green circles indicate S1-S2 programmed ventricular stimulation. Red arrows highlight non-conducted p-waves. Bidirectional VT was induced by treatment with epinephrine and caffeine. E. Longest duration of VT. VT duration was greater in CKO mice, although this was not statistically significant at these low sample sizes. Permutation test.