Table 3. Factors Associated with Self-Reported Moderate Physical Activity: SAGE-AF Study.
Model 1: Adjusting for sociodemographic and clinical factors and smoking status; Model 2: M1 + Geriatric Elements; Model 3: Model 1 + Model 2 + patient reported outcomes; Abbreviations: TIA: Transient Ischemic Attack; CHA2DS2-VASc: Stroke risk assessment; HAS-BLED: Bleeding risk assessment; MOCA: Montreal Cognitive Assessment; PHQ-9: Patient Health Questionnaire 9; GAD-7: Generalized Anxiety Disorder; AFEQT: Atrial Fibrillation Effect on Quality of Life.
| Model 1 Adjusted OR (95 % CI) | Model 2 Adjusted OR (95 % CI) | Model 3 Adjusted OR (95 % CI) | |
|---|---|---|---|
| Socio-demographic | |||
| Age (yrs) | |||
| 65-74 | Ref. | Ref. | Ref. |
| 75-84 | 0.71 (0.51, 0.97) | 0.74 (0.53, 1.03) | 0.73 (0.52, 1.02) |
| 85+ | 0.51 (0.33, 0.79) | 0.66 (0.42, 1.05) | 0.63 (0.40, 1.00) |
| Sex (Female vs Male) | 0.81 (0.60, 1.10) | 0.88 (0.64, 1.21) | 0.91 (0.66, 1.25) |
| Married (No vs Yes) | 0.89 (0.69, 1.16) | 0.97 (0.74, 1.27) | 0.97 (0.74, 1.28) |
| Non-Hispanic White (Yes vs No) | 1.25 (0.88, 1.78) | 0.92 (0.63, 1.34) | 0.90 (0.61, 1.32) |
| College Graduate (Yes vs No) | 1.36 (1.06, 1.74) | 1.19 (0.92, 1.55) | 1.16 (0.89, 1.51) |
| Clinical | |||
| Body Mass Index (BMI), kg/m2 | |||
| Normal | Ref. | Ref. | Ref. |
| Overweight | 0.90 (0.64, 1.27) | 0.88 (0.62, 1.25) | 0.86 (0.60, 1.23) |
| Overweight | 0.90 (0.64, 1.27) | 0.88 (0.62, 1.25) | 0.86 (0.60, 1.23) |
| Obese | 0.72 (0.51, 1.02) | 0.70 (0.49, 1.00) | 0.71 (0.50, 1.02) |
| Morbidly Obese | 0.35 (0.20, 0.61) | 0.39 (0.22, 0.70) | 0.41 (0.23, 0.73) |
| Type of AF (%) | |||
| Paroxysmal | Ref. | Ref. | Ref. |
| Persistent | 0.98 (0.73, 1.31) | 0.99 (0.74, 1.34) | 1.04 (0.77, 1.30) |
| Permanent | 0.69 (0.41, 1.17) | 0.61 (0.36, 1.04) | 0.65 (0.38, 1.11) |
| Medical History | |||
| Alcohol Use | 1.32 (0.97, 1.78) | 1.16 (0.85, 1.59) | 1.12 (0.81, 1.54) |
| Anemia | 1.03 (0.78, 1.35) | 1.08 (0.82, 1.44) | 1.07 (0.81, 1.42) |
| Asthma/COPD | 0.82 (0.62, 1.10) | 0.86 (0.64, 1.16) | 0.91 (0.67, 1.22) |
| Diabetes | 0.95 (0.69, 1.31) | 1.01 (0.72, 1.41) | 0.99 (0.71, 1.38) |
| Heart Failure | 0.69 (0.51, 0.94) | 0.79 (0.57, 1.09) | 0.83 (0.60, 1.15) |
| Hypertension | 0.91 (0.60, 1.39) | 0.99 (0.63, 1.53) | 0.95 (0.61, 1.48) |
| Myocardial Infarction | 0.78 (0.55, 1.10) | 0.73 (0.51, 1.04) | 0.72 (0.51, 1.03) |
| Peripheral vascular disease | 0.78 (0.54, 1.14) | 0.79 (0.53, 1.16) | 0.78 (0.53, 1.14) |
| Renal Disease | 0.76 (0.54, 1.06) | 0.71 (0.50, 1.00) | 0.68 (0.48, 0.96) |
| Stroke/TIA | 0.78 (0.48, 1.25) | 0.83 (0.50, 1.35) | 0.78 (0.48, 1.29) |
| Risk Scores | |||
| CHA2DS2-VASc | 1.05 (0.90, 1.22) | 1.08 (0.92, 1.27) | 1.09 (0.93, 1.28) |
| HAS-BLED | 0.94 (0.79, 1.11) | 0.98 (0.82, 1.17) | 1.00 (0.84, 1.20) |
| Geriatric Elements | |||
| Gait Speed | |||
| Normal | Ref. | Ref. | |
| Slow | 0.45 (0.33, 0.61) | 0.44 (0.32, 0.60) | |
| Cognitive Impairment (MOCA) | 0.75 (0.57, 0.99) | 0.74 (0.56, 0.97) | |
| Social Isolation | 0.55 (0.38, 0.81) | 0.58 (0.40, 0.84) | |
| Depression (PHQ-9 ≥ 5) | 0.68 (0.49, 0.94) | 0.76 (0.55, 1.05) | |
| Anxiety (GAD-7 ≥5) | 0.85 (0.61, 1.20) | 0.93 (0.66, 1.31) | |
| Fall in the Past 6 months | 0.92 (0.68, 1.24) | 0.96 (0.71, 1.30) | |
| Visual Impairment | 0.82 (0.63, 1.07) | 0.85 (0.65, 1.12) | |
| Patient Reported Outcome | |||
| AFEQT >80 | 1.64 (1.25, 2.16) |