Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 23;42(1):49–62. doi: 10.1161/ATVBAHA.121.317113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 American Heart Association, Inc.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

PMC Copyright notice

Figure 1. — The platelet proteome in acute ST-segment–elevation myocardial infarction (STEMI). Washed platelets from 30 individuals experiencing acute STEMI and 25 with severe, stable CAD before CABG surgery underwent proteomic analysis using tandem mass tagged multiplexing. A, Volcano plot highlighting proteins with FDR <0.1 and FC of median value ≥1.5 (orange) or ≥2.0 (red) thresholds. B, Inflammation-related proteins LTF (lactotransferrin), neutrophil DEFA1 (defensin A1), S100A8, and S100A9 were increased in STEMI patients compared with stable CAD (LTF: FC, 1.85; P=2.6×10⁻⁶; FDR, 0.006; DEFA: FC, 1.77; P=2.5×10⁻⁶; FDR, 0.006; S100A8: FC, 2.00; P=2.2×10⁻⁵; FDR, 0.05; S100A9: FC, 2.28; P=2.4×10⁻⁶; FDR, 0.005).