Table 3.

Multivariate Cox regression analysis for OS and CSS in SBA patients (training cohort).

Characteristics	Overall survival		Cancer specific survival
	HR (95%CI)	P-value	HR (95%CI)	P-value
Age
<60	Reference		Reference
60–69	1.271(1.046–1.544)	0.016	1.215(0.996–1.483)	0.056
70–79	1.783(1.453–2.190)	<0.001	1.610(1.296–2.000)	<0.001
≥80	2.024(1.607–2.550)	<0.001	2.233(1.742–2.862)	<0.001
Sex
Female	Reference		Reference
Male	1.171(1.012–1.355)	0.034	1.195(1.022–1.397)	0.026
Primary site
Duodenum	Reference		Reference
Jejunum	0.831(0.654–1.055)	0.127	0.928(0.723–1.191)	0.555
Ileum	0.884(0.695–1.124)	0.314	1.082(0.844–1.389)	0.533
Other	1.039(0.809–1.334)	0.532	1.030(0.787–1.347)	0.831
Grade
I/II	Reference		Reference
III/IV	1.612(1.395–1.863)	<0.001	1.786(1.529–2.085)	<0.001
T stage
T1/T2	Reference		Reference
T3	1.108(0.863–1.422)	0.421	0.927(0.713–1.205)	0.572
T4	1.692(1.348–2.122)	<0.001	1.608(1.272–2.033)	<0.001
TX	1.786(1.361–2.344)	<0.001	1.325(1.004–1.750)	0.047
N stage
N0	Reference		Reference
N1	1.414(1.180–1.693)	<0.001	1.445(1.191–1.754)	<0.001
N2	2.112(1.675–2.664)	<0.001	2.330(1.830–2.967)	<0.001
NX	0.930(0.689–1.256)	0.636	0.991(0.720–1.363)	0.955
Metastasis status
No	Reference		Reference
Liver metastasis	2.762(2.205–3.461)	<0.001	2.316(1.830–2.932)	<0.001
Bone/Brain/Lung metastasis	2.857(1.971–4.142)	<0.001	2.432(1.699–3.480)	<0.001
≥2 sites	3.236(2.135–4.905)	<0.001	2.970(1.995–4.420)	<0.001
Other	2.108(1.694–2.623)	<0.001	1.921(1.526–2.418)	<0.001
Surgery
No	Reference		Reference
Yes	0.445(0.335–0.591)	<0.001	0.419(0.310–0.566)	<0.001
Retrieval of regional lymph nodes
0	Reference		Reference
1–3	1.085(0.801–1.470)	0.598	1.343(0.823–1.563)	0.441
≥4	0.610(0.469–0.793)	<0.001	0.500(0.377–0.664)	<0.001
Radiation
No	Reference		Reference
Yes	1.127(0.874–1.454)	0.357	0.987(0.760–1.283)	0.923
Chemotherapy
No	Reference		Reference
Yes	0.502(0.426–0.592)	<0.001	0.547(0.459–0.651)	<0.001