Table 3.
Summary of Disease Progression Outcomes Determined by Diagnostic Imaging of Canine Elbow Joints 180 Days After Injection with Tin-117m
| Imaging Method & No. IA Injections | IA Osteoarthritis Progression in Treated Elbows | ||
|---|---|---|---|
| Improved | No Change | Worse | |
| Radiograph* | |||
| 1 Injection | 0/7 (0%) | 4/7 (57.1%) | 3/7 (42.9%) |
| 2 Injections | 0/9 (0%) | 4/9 (44.4%) | 5/9 (55.6%) |
| CT* | |||
| 1 Injection | 0/8 (0%) | 4/8 (50.0%) | 4/8 (50.0%) |
| 2 Injections | 0/10 (0%) | 7/10 (70.0%) | 3/10 (30.0%) |
| MRI* | |||
| 1 Injection | 1/8 (12.5%) | 3/8 (37.5%) | 4/8 (50.0%) |
| 2 Injections | 0/9 (0%) | 3/9 (33.3%) | 6/9 (66.7%) |
| All Images | |||
| 1 Injection | 1/23 (0.4%) | 11/23 (47.8%) | 11/23 (47.8%) |
| 2 Injection | 0/28 (0%) | 14/28 (50.0%) | 14/28 (50.0%) |
Notes: *Radiographs and MRI scans were obtained for 9 dogs in the per-protocol (PP) population. CT scans were obtained for 10 dogs in the intent-to-treat population.
Abbreviations: CT, computed tomography; IA, intraarticular; MRI, magnetic resonance imaging.