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(A) RMSF plot of the ACE2 residues in different systems: ACE2 apo form (black line), ACE2 complexed with BAR708 (brown line) and BAR107 (magenta line). (B) Open native state of ACE2 highlighting the most fluctuating residues from RMSF analysis. RMSF was calculated on Cα atoms aligning on the α-helices of Sub II.
