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Changes over time in representative immunohistochemical images. Immunohistochemistry with (A–C) alpha smooth muscle actin and (D–F) von Willebrand factor. Asterisks (*) indicate small blood vessels in bridging tissue. Arrows (→) indicate endothelial cells. (A, D) 12 months, (B, E) 24 months and (C, F) 36 months after implantation.
