Table 1. Characteristics of 219 hemochromatosis probands with HFE p.C282Y homozygositya.
| Characteristic | Cirrhosis (n = 22) | No cirrhosis (n = 197) | Value of p |
|---|---|---|---|
| Male, % (n) | 86.4 (19) | 53.8 (106) | 0.0030 |
| Mean age at diagnosis, y, ± 1 SD | 52 ± 9 | 48 ± 14 | 0.0451 |
| Diabetes, % (n)b | 22.7 (5) | 14.2 (28) | 0.3417 |
| Heavy alcohol consumption, % (n) | 22.7 (5) | 5.1 (10) | 0.0099 |
| Abdominal pain, % (n) | 22.7 (5) | 1.5 (3) | 0.0003 |
| Abdominal tenderness, % (n) | 13.6 (3) | 2.0 (4) | 0.0238 |
| Hepatomegaly, % (n) | 45.5 (10) | 12.2 (24) | 0.0004 |
| Splenomegaly, % (n) | 13.6 (3) | 1.0 (2) | 0.0078 |
| NAFLD, % (n) | 27.3 (6) | 21.8 (43) | 0.5914 |
| Chronic viral hepatitis, % (n)c | 18.2 (4) | 1.5 (3) | 0.0022 |
| Ascites, % (n) | 4.8 (1) | 0.5 (1) | 0.1912 |
| Mean hemoglobin, g/L, ± 1 SD | 140 ± 18 | 147 ± 15 | 0.1559 |
| Median TS, % (n) (range) | 89 (34, 100) | 70 (19, 100) | 0.0235 |
| Median SF, μg/L (range) | 2000 (387, 5613) | 650 (15, 6103) | <0.0001 |
| Median QFe, g (range) | 6.3 (1.0, 31.2) | 2.6 (0, 30.0) | <0.0001 |
aAbbreviations: NAFLD, non-alcoholic fatty liver disease; QFe, quantity of iron removed by phlebotomy to achieve iron depletion; SD, standard deviation; SF, serum ferritin; TS, transferrin saturation.
bThirty-one probands had type 2 diabetes. Two other probands had type 1 diabetes.
cFive probands had chronic viral hepatitis C. Two other probands had chronic viral hepatitis B. No proband was treated with anti-viral therapy for chronic viral hepatitis before diagnosis of hemochromatosis.