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Histological sections of normal (A) and Zfr homozygous mutant (B) E6.5 embryos stained with hematoxylin and eosin. (C) A magnified view of the distal tip of the mutant embryo, from the box in panel B. Pyknotic cells (pyk) can be observed in the embryonic ectoderm and in the proamniotic cavity (pa). eee, extraembryonic ectoderm; ee, embryonic ectoderm; ve, visceral endoderm; j, junction between embryonic and extraembryonic regions.
