TABLE 2.
Ibrutinib pharmacokinetic parameters predicted from a physiologically based pharmacokinetic model of drug–drug interaction between ibrutinib and cobicistat.
| Ibrutinib dose (mg) | Cobicistat dose (mg) | T max (h) | C max (ng/mL) | AUC (ng/h/mL) | AUCinh/AUC ratio | CL (L/hour) |
|---|---|---|---|---|---|---|
| 420 | — | 1.93 (0.83) | 58.4 (53.7) | 468 (499) | 1,600 (1,167) | |
| 420 | 200 | 3.02 (1.18) | 509 (295) | 7,497 (4,934) | 20.4 (12.0) | 84.5 (60.6) |
| 23 | — | 1.46 (0.24) | 4.77 (4.05) | 28 (32) | 1,521 (1,129) | |
| 23 | 200 | 1.80 (0.37) | 38.9 (19.5) | 476 (326) | 22.3 (15.1) | 74.6 (54.2) |
NOTE: Values are the mean with SD in parenthesis.
Abbreviations: AUCinh, AUC in the presence of cobicistat; CL, clearance; Tmax, time of maximum plasma concentration.