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. 2021 Dec 21;2021(12):CD002042. doi: 10.1002/14651858.CD002042.pub5

Maitland 2019.

Methods RCT (multicentre; Uganda, Malawi)
Participants Children aged 2 months to 12 years (median 37 months) with haemoglobin level < 6 g/dL and severity features
Interventions Complex. The main intervention involved receipt of immediate blood transfusion with 20 mL/kg or 30 mL/kg. Three other randomised analyses also investigated:
  • immediate compared with no immediate transfusion;

  • provision of postdischarge micronutrients; and

  • postdischarge prophylaxis with trimethoprim–sulfamethoxazole

Outcomes Primary outcome: 28‐day mortality
Notes Trial registration (prospective): ISRCTN84086586