NCT03229941.

Study name	Transfusion Trigger after Operations in High Cardiac Risk Patients (TOP)
Methods	RCT (multicentre)
Participants	The trial will include people having: open (non‐endovascular) PAD‐related operations; and selected major vascular and general operations with a prior history of PAD or IHD Estimated enrolment: 3070
Interventions	Liberal group: transfusion trigger at Hb < 10 g/dL Restrictive group: transfusion trigger at Hb < 7 g/dL
Outcomes	A composite endpoint of all‐cause post‐randomisation mortality, myocardial infarction, coronary revascularization, acute renal failure, or post‐randomisation ischaemic stroke up to 90 days after randomisation
Starting date	2018
Contact information	Panagiotis Kougias; panagiotis.kougias@va.gov Sherene Sharath; sherene,sharath@va.gov
Notes	Trial registration (prospective): NCT03229941 Sponsor: Veterans Affairs Office of Research and Development (USA)