Table 3.
Univariate Associations With Death and/or MI and MACE, According to the Presence of MI in the Entire Cohort and in Patients Without Ischemia on Stress CMR
| No MI | UMI | RMI | MI vs. no MI | UMI vs. RMI | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
|
| |||||||
| Entire Cohort | (n = 1,644) | (n = 347) | (n = 358) | ||||
| Death and/or MI* | 170 (10.3) | 73 (21.0) | 85 (23.7) | 2.30 (1.85–2.86) | <0.001 | 0.88 (0.64–1.21) | 0.43 |
| All-cause death† | 148 (9.0) | 61 (17.6) | 46 (12.8) | 1.72 (1.34–2.21) | <0.001 | 1.41 (0.96–2.08) | 0.077 |
| MI† | 24 (1.5) | 17 (4.9) | 46 (12.8) | 6.45 (4.02–10.3) | <0.001 | 0.39 (0.22–0.68) | <0.001 |
| MACE† | 268 (16.3) | 126 (36.3) | 134 (37.4) | 2.55 (2.15–3.03) | <0.001 | 0.94 (0.74–1.20) | 0.63 |
| CV death | 28 (1.7) | 26 (7.5) | 20 (5.6) | 3.95 (2.47–6.33) | <0.001 | 1.42 (0.79–2.54) | 0.24 |
| Hospitalization for HF | 49 (3.0) | 41 (11.8) | 18 (5.0) | 2.93 (2.00–4.30) | <0.001 | 2.60 (1.48–4.58) | <0.001 |
| Hospitalization for UA | 63 (3.8) | 27 (7.8) | 49 (13.7) | 3.02 (2.15–4.23) | <0.001 | 0.58 (0.36–0.93) | 0.023 |
| Late unplanned CABG | 19 (1.2) | 14 (4.0) | 18 (5.0) | 3.92 (2.21–6.93) | <0.001 | 0.78 (0.38–1.58) | 0.485 |
| VT and/or VF | 13 (0.8) | 6 (1.7) | 14 (3.9) | 3.66 (1.81–7.41) | <0.001 | 0.43 (0.16–1.14) | 0.081 |
|
| |||||||
| No ischemia on stress CMR | (n = 1,473) | (n = 229) | (n = 242) | ||||
| Death and/or MI* | 148 (10.1) | 42 (18.3) | 52 (21.5) | 2.11 (1.63–2.74) | <0.001 | 0.86 (0.57–1.30) | 0.473 |
| All-cause death† | 133 (9.0) | 38 (16.6) | 32 (13.2) | 1.69 (1.26–2.26) | <0.001 | 1.32 (0.82–2.11) | 0.254 |
| MI† | 17 (1.1) | 7 (3.1) | 25 (10.3) | 6.30 (3.50–11.35) | <0.001 | 0.31 (0.13–0.71) | 0.003 |
| MACE† | 219 (14.9) | 73 (31.9) | 77 (31.8) | 2.36 (1.91–2.91) | <0.001 | 1.01 (0.73–1.40) | 0.95 |
| CV death | 24 (1.6) | 11 (4.8) | 14 (5.8) | 3.39 (1.94–5.94) | <0.001 | 0.89 (0.40–1.96) | 0.771 |
| Hospitalization for HF | 37 (2.5) | 24 (10.5) | 9 (3.7) | 2.89 (1.79–4.65) | <0.001 | 3.39 (1.52–7.54) | 0.002 |
| Hospitalization for UA | 46 (3.1) | 15 (6.6) | 25 (10.3) | 2.88 (1.88–4.40) | <0.001 | 0.64 (0.34–1.21) | 0.168 |
| Late unplanned CABG | 13 (0.9) | 5 (2.2) | 9 (3.7) | 2.97 (1.40–6.33) | 0.003 | 0.51 (0.16–1.65) | 0.252 |
| VT and/or VF | 11 (0.8) | 3 (1.3) | 8 (3.3) | 3.18 (1.37–7.38) | <0.007 | 0.39 (0.10–1.48) | 0.166 |
Values are n or n (%), unless otherwise indicated. N = 2,349; no ischemia on stress CMR, n = 1,944. HRs are unadjusted. Statistical analysis by log-rank test.
*
Only p values for the primary outcome are confirmatory.
†
There was no multiplicity adjustment for the testing of these outcomes.