Table II.
Parameter | Normal | TAC | Sham | TAC + EGCG | Vehicle | F-value | P-value |
---|---|---|---|---|---|---|---|
Body weight, g | 38.28±0.31 | 39.11±0.15 | 38.42±0.38 | 38.43±0.48 | 38.43±0.48 | 2.24 | 0.1400 |
Heart rate, bpm) | 465.00±4.00 | 468.00±3.00 | 464.00±54.00 | 462.00±3.00 | 461.00±1.00 | 2.47 | 0.1100 |
LV end diastole | |||||||
AWT, mm | 1.04±0.04 | 1.23±0.68a | 1.04±0.13 | 1.07±0.05b | 1.03±0.01 | 21.25 | <0.0001 |
IVS, mm | 0.83±0.15 | 1.02±0.16a | 0.84±0.26 | 0.92±0.15b | 0.85±0.10 | 44.18 | <0.0001 |
Dimension, mm | 2.92±0.72 | 3.29±0.29a | 2.85±0.50 | 3.01±0.13b | 2.80±0.62 | 15.56 | <0.0001 |
Volume, µl | 75.33±0.74 | 80.00±1.00a | 75.81±0.75 | 77.80±0.12b | 75.12±0.49 | 27.27 | <0.0001 |
LV end systole | |||||||
AWT, mm | 1.43±0.04 | 1.88±0.03a | 1.45±0.06 | 1.63±0.04b | 1.47±0.04 | 65.78 | <0.0001 |
IVS, mm | 1.08±0.15 | 1.06±0.10 | 1.07±0.10 | 1.09±0.15 | 1.07±0.10 | 1.89 | 0.1900 |
Dimension, mm | 1.12±0.03 | 1.43±0.03a | 1.17±0.02 | 1.30±0.02b | 1.14±0.02 | 48.72 | <0.0001 |
Volume, µl | 21.63±1.34 | 29.88±0.96a | 22.81±0.71 | 24.78±0.77b | 23.32±1.02 | 27.56 | <0.0001 |
EF, % | 82.33±2.52 | 61.00±5.29a | 84.67±4.51 | 76.33±2.52b | 84.33±4.16 | 18.90 | <0.0001 |
TAC, thoracic aorta constriction; EGCG, epigallocatechin gallate; LV, left ventricular; AWT, anterior wall thickness; IVS, interventricular septum; EF, ejection fraction. Data are presented as the mean ± SD.
P<0.05 vs. normal;
P<0.05 vs. TAC.