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. 2021 Dec 14;2021:2895893. doi: 10.1155/2021/2895893

Figure 2.

Figure 2

The function of miR-138 on B cell maturation in Tfh cells of patients with OS. (a) qRT-PCR verification of miR-138 expression in Tfh cells after interference or overexpression of miR-138. (b) Determination of the level of CD40L in Tfh cells of OS patients using flow cytometry. (c) The positive proportion changes of CD27 and CD38 in B cells after coculturing with CD4+CXCR5+ Tfh cells using flow cytometry detection. The level changes of (d) IgM, (e) IgG, (f) IL-10, and (g) IL-21 in the medium after coculturing with CD4+CXCR5+ Tfh cells using ELISA detection. P < 0.05 and ∗∗P < 0.01vs. the NC mimics group; #P < 0.05 and ##P < 0.01vs. the NC inhibitor group.