Table 3.
OR and P value for probable significant variants with insufficient data.
| Gene | Variant | Alleles | Ethnicity | MAF† | Studies | Number evaluation | Risk of meta-analysis | PQ | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample size (case/control) | Genetic models | Effect model | OR (95%CI) | P value | I (%) | |||||||
| CYP1A2F | rs762551 | A > C | Caucasian | 0.44 | 2 | 688 (170/518) | Recessive | F | 1.921 (1.163 − 3.174) | ≤0.01 | 0.0 | 0.55 |
| FTO | rs1477196 | G > A | Overall | 0.32 | 2 | 2188 (1044/1144) | Allelic | F | 1.176 (1.037 − 1.334) | ≤0.01 | 43.7 | 0.18 |
| FTO | rs8047395 | A > G | Overall | 0.42 | 2 | 2191 (1046/1145) | Allelic | R | 1.235 (1.009 − 1.511) | 0.04 | 61.8 | 0.11 |
| FTO | rs11642841 | C > A | Overall | 0.18 | 2 | 2195 (1046/1149) | Allelic | F | 0.784 (0.653 − 0.941) | ≤0.01 | 38.3 | 0.20 |
| FTO | rs17817288 | G > A | Overall | 0.44 | 2 | 2194 (1045/1149) | Recessive | F | 1.410 (1.148 − 1.732) | ≤0.01 | 0.0 | 0.60 |
| IL-18-127C-T | rs360717 | C > T | Overall | 0.34 | 2 | 721 (130/591) | Allelic | F | 1.652 (1.192 − 2.288) | ≤0.01 | 25.4 | 0.27 |
| miR-608 | rs4919510 | G > C | Asian | 0.42 | 2 | 2975 (1193/1782) | Recessive | F | 0.813 (0.664 − 0.997) | 0.05 | 0.0 | 0.40 |
| TSHR | rs1991517 | A > C | Overall | 0.27 | 2 | 1239 (566/673) | Allelic | F | 1.250 (1.046 − 1.494) | ≤0.01 | 0.0 | 0.83 |
| XRCC3 | rs56377012 | A > G | Asian | 0.07 | 2 | 1229 (459/770) | Recessive | F | 9.421 (4.581 − 19.378) | ≤0.01 | 0.0 | 0.86 |
F: meta-analysis was performed under the fixed-effects model. R: meta-analysis was performed under the random-effects model. Overall: two or more ethnicities were reported in the study. †Frequency of minor allele in controls.