Table 2.
GO and KEGG enrichment analysis of DEPs following ICH.
| Ontology | ID | Description | GeneRatio | BgRatio | p value | p.adjust | q value |
|---|---|---|---|---|---|---|---|
| BP | GO:0007596 | Blood coagulation | 19/333 | 156/23210 | 1.18e − 12 | 2.12e − 09 | 1.50e − 09 |
| BP | GO:0007599 | Hemostasis | 19/333 | 158/23210 | 1.49e − 12 | 2.12e − 09 | 1.50e − 09 |
| BP | GO:0050817 | Coagulation | 19/333 | 159/23210 | 1.67e − 12 | 2.12e − 09 | 1.50e − 09 |
| BP | GO:0042060 | Wound healing | 27/333 | 360/23210 | 2.87e − 12 | 2.74e − 09 | 1.94e − 09 |
| BP | GO:0009611 | Response to wounding | 31/333 | 495/23210 | 7.37e − 12 | 5.63e − 09 | 3.98e − 09 |
| CC | GO:0062023 | Collagen-containing extracellular matrix | 29/339 | 359/23436 | 8.19e − 14 | 3.58e − 11 | 2.56e − 11 |
| CC | GO:0031012 | Extracellular matrix | 32/339 | 475/23436 | 5.96e − 13 | 1.30e − 10 | 9.31e − 11 |
| CC | GO:0015629 | Actin cytoskeleton | 23/339 | 490/23436 | 8.83e − 07 | 1.29e − 04 | 9.20e − 05 |
| CC | GO:0005764 | Lysosome | 21/339 | 431/23436 | 1.48e − 06 | 1.34e − 04 | 9.57e − 05 |
| CC | GO:0000323 | Lytic vacuole | 21/339 | 432/23436 | 1.53e − 06 | 1.34e − 04 | 9.57e − 05 |
| MF | GO:0003779 | Actin binding | 25/327 | 428/22710 | 3.77e − 09 | 2.39e − 06 | 1.96e − 06 |
| MF | GO:0004857 | Enzyme inhibitor activity | 22/327 | 384/22710 | 4.70e − 08 | 1.44e − 05 | 1.18e − 05 |
| MF | GO:0061135 | Endopeptidase regulator activity | 16/327 | 209/22710 | 6.80e − 08 | 1.44e − 05 | 1.18e − 05 |
| MF | GO:0061134 | Peptidase regulator activity | 17/327 | 244/22710 | 1.04e − 07 | 1.65e − 05 | 1.35e − 05 |
| MF | GO:0004867 | Serine-type endopeptidase inhibitor activity | 11/327 | 118/22710 | 1.13e − 06 | 1.44e − 04 | 1.18e − 04 |
| KEGG | mmu04610 | Complement and coagulation cascades | 15/169 | 93/8910 | 1.72e − 10 | 4.38e − 08 | 4.12e − 08 |
| KEGG | mmu04611 | Platelet activation | 10/169 | 124/8910 | 1.17e − 04 | 0.015 | 0.014 |
| KEGG | mmu04142 | Lysosome | 10/169 | 131/8910 | 1.85e − 04 | 0.016 | 0.015 |
| KEGG | mmu04612 | Antigen processing and presentation | 8/169 | 91/8910 | 3.17e − 04 | 0.020 | 0.019 |
| KEGG | mmu05133 | Pertussis | 7/169 | 77/8910 | 6.15e − 04 | 0.031 | 0.029 |