Figure 6.

Interpretation of the maximum fitted circular, rectangular and elliptical shaped devices in the PRSP. Predicted versus actual plot for the observations using a quadratic support vector machine (SVM) regression model for each shape (a,d,g). Confusion matrix for the classification model for each shape where the class labels were defined as the percentile bands of the average area of the maximal fitted devices (less than 25th, 25–49th, 50–74th and greater than or equal to 75th percentile) (b,e,h). Number of cells (IEQ kg⁻¹) that can be delivered using two devices based on the calculation that one IEQ corresponds to the tissue volume of a perfectly spherical islet with a diameter of 150 µm [39]. Thickness of 0.6 mm is assigned to devices and islet density of 10% of the volume fraction. The percentage of patients that achieve a therapeutic dose of 10 000 IEQ kg⁻¹ is shown per percentile category for circular, rectangular and elliptical shaped devices in the PRSP (c,f,i).