Table 3.
Associations of single nucleotide polymorphisms (SNPs) with gastric cancer risk among CagA-seropositive cases and controls
| Chromosome | SNP | Gene | Adjusted OR (95% CI)* |
p- value |
|---|---|---|---|---|
| 1 | rs1801131 | MTHFR | 0.835 | |
| 1 | rs1801133 | MTHFR | 0.428 | |
| 1 | rs1846522 | FAF1 | 0.36 | |
| 1 | rs1137101 | LEPR | 0.95 | |
| 1 | rs5845 | SELENOF | 0.65 | |
| 1 | rs1800871 | IL10 | 0.566 | |
| 1 | rs1800896 | IL10 | 0.543 | |
| 2 | rs2302615 | ODC1 | 1.36 (1.05, 1.75) | 0.02 |
| 2 | rs1800440 | CYP1B1 | 0.77 (0.54, 1.02) | 0.069 |
| 2 | rs1056836 | CYP1B1 | 0.77 (0.57, 0.95) | 0.008 |
| 2 | rs10197208 | GKN3P | 0.655 | |
| 2 | rs1143634 | IL1B | 0.982 | |
| 2 | rs1143627 | IL1B | 0.257 | |
| 2 | rs16944 | IL1B | 0.206 | |
| 2 | rs419598 | IL1RN | 0.913 | |
| 2 | rs1063728 | RPRM | 0.873 | |
| 2 | rs61261057 | UGT1A10 | 0.969 | |
| 2 | rs17868323 | UGT1A10 | 0.291 | |
| 2 | rs11692021 | UGT1A10 | 0.54 (0.69, 1.03) | 0.096 |
| 3 | rs35683 | GHRL | 0.81 (0.67, 0.97) | 0.024 |
| 3 | rs9841504 | ZBTB20 | 0.452 | |
| 4 | rs4129009 | TLR10 | 0.72 (0.54, 0.94) | 0.018 |
| 4 | rs4543123 | TLR1 | 0.81 (0.65, 1.00) | 0.053 |
| 4 | rs5743604 | TLR1 | 0.15 (0.97, 1.36) | 0.099 |
| 4 | rs6815814 | TLR1 | 0.389 | |
| 4 | rs4588 | GC | 0.364 | |
| 4 | rs7041 | GC | 0.596 | |
| 4 | rs4073 | CXCL8 | 0.47 | |
| 5 | rs13361707 | PRKAA1 | 0.095 | |
| 5 | rs7579 | CCDC152 | 0.687 | |
| 5 | rs3877899 | CCDC152 | 0.751 | |
| 6 | rs3020314 | ESR1 | 0.492 | |
| 6 | rs4880 | SOD2 | 0.344 | |
| 7 | rs2066853 | AHR | 0.284 | |
| 7 | rs1800795 | IL6 | 0.235 | |
| 8 | rs5030839 | NAT1 | 0.572 | |
| 8 | rs15561 | NAT1 | 0.756 | |
| 8 | rs1041983 | NAT2 | 0.178 | |
| 8 | rs1799929 | NAT2 | 0.186 | |
| 8 | rs1799930 | NAT2 | 0.464 | |
| 8 | rs1799931 | CYP2C9 | 0.293 | |
| 8 | rs2294008 | PSCA | 0.336 | |
| 9 | rs1927914 | TLR4 | 1.34 (1.08, 1.54) | 0.005 |
| 9 | rs505922 | ABO | 0.277 | |
| 10 | rs10508902 | ARHGAP22 | 0.924 | |
| 10 | rs2031920 | CYP2E1 | 0.658 | |
| 11 | rs12794714 | CYPR1 | 0.937 | |
| 11 | rs2060793 | CYPR1 | 0.533 | |
| 11 | rs12800438 | NADSYN1 | 1.19 (1.01, 1.42) | 0.04 |
| 11 | rs3829251 | NADSYN1 | 0.83(0.69,1.01) | 0.061 |
| 11 | rs530537 | CASP1 | 1.20 (1.01, 1.43) | 0.034 |
| 14 | rs4986938 | ESR2 | 0.115 | |
| 14 | rs1950902 | MTHFD1 | 0.51 | |
| 14 | rs2236225 | MTHFD1 | 0.267 | |
| 15 | rs762551 | CYP1A2 | 0.391 | |
| 16 | rs16260 | CDH1 | 0.83 (0.68, 1.00) | 0.05 |
| 17 | rs2297518 | NOS2 | 0.588 | |
| 17 | rs7220169 | GAST | 0.832 | |
| 19 | rs713041 | GPX4 | 0.653 | |
| 19 | rs1800469 | B9D2 | 0.953 | |
| 20 | rs13042395 | SLC52A3 | 0.17 | |
| 20 | rs6116569 | SLC23A2 | 0.286 | |
| 20 | rs6133175 | SLC23A2 | 0.957 | |
| 20 | rs6053005 | SLC23A2 | 0.197 | |
| 20 | rs17217119 | CYP24A1 | 0.558 | |
| 21 | rs225439 | TFF3 | 0.185 |
*
Odds ratio adjusted for age and sex are shown if p <0.10
FDR significant values are bolded (p < 0.021)