Table 2. Summary of large cohort studies on PTL and surgical outcomes after resection for Stage I - III CRC.
| Year | Reference | Study type | Study period | Number of patients | Survival analysis for RCC versus LCC |
|---|---|---|---|---|---|
| 2008 | Meguid et al. (4) | Retrospective (SEER database) |
1988-2003 | 77,978 | Stage I: no difference in OS Stage II: superior in OS (HR 0.91, 95% CI 0.88-0.95) Stage III: inferior in OS (HR 1.06, 95% CI 1.02-1.11) |
| 2016 | Kerr et al. (17) | Retrospective (Two trials) |
2002-2004 2005-2010 |
1,935 | Stage II-III: no difference in RFS, but inferior in OS after recurrence (HR 1.53, 95% CI 1.14-2.06) |
| 2018 | Ishihara et al. (16) | Retrospective (22 centers) |
1997-2006 | 5,664 | Stage II-III: superior in RFS, but inferior in 5-year CSS after recurrence (30.6% versus 43.6%) |
| 2019 | Turner et al. (14) | Retrospective (NCDB) |
2006-2013 | 185,863 | Stage I-II: superior in OS (HR 0.88, 95% CI 0.85-0.92) Stage III with chemotherapy: inferior in OS (HR 1.18, 95% CI 1.12-1.22) Stage III without chemotherapy: no difference in OS |
| 2019 | Cascinu et al. (18) | Retrospective (Three trials) |
1989-1992 1992-1998 2007-2013 |
5,239 | Stage II: no difference in DFS and OS Stage III: no difference in DFS, but inferior in OS (HR 1.35, 95% CI 1.14-1.62) |
| 2020 | Shida et al. (19) | Retrospective (24 centers) |
1997-2012 | 9,194 | Stage III: inferior in 5-year OS after recurrence (RCC: 23.3%, LCC: 36.6%, rectal cancer: 31.6%) |
CI, confidence interval; CRC, colorectal cancer; CSS, cancer specific survival; DFS, disease free survival; HR, hazard ratio; LCC, left-sided colon cancer; NCDB, The National Cancer Database; OS, overall survival; PTL, primary tumor location; RCC, right-sided colon cancer; RFS, recurrence free survival; SEER, surveillance, epidemiology, and end results.