Figure 2.

Cyclin E1 and MMP9 are positively correlated with G6PD and associated with poor outcomes in ccRCC patients. (A-C) mRNA expression levels of Cyclin D1, Cyclin E1 and MMP9 in normal kidney tissues (n=72) and ccRCC specimens (n=535) were analyzed by TCGA dataset mining (Mann-Whitney U test). (D-F) Spearman correlation analyses between G6PD and Cyclin D1, G6PD and Cyclin E1, G6PD and MMP9 at the mRNA expression levels were conducted in ccRCC and normal kidney tissues. (G-O) Kaplan-Meier analyses for overall survival of all ccRCC patients (n=528), patients with stage I/II ccRCC (n=320) and patients with stage III/IV ccRCC (n=205) in the TCGA cohort with high vs. low indicated gene mRNA expression levels were shown (log-rank test).