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. 2022 Jan 1;18(1):30–42. doi: 10.7150/ijbs.65255

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Aberrant methylation contributes to the silencing of IRF7 in OS. (A) The mRNA level of IRF7 in 5 OS cell lines and the nonmalignant hFOB1.19 cells was analyzed by real-time qPCR. (B) The protein level of IRF7 in 5 OS cell lines and the nonmalignant hFOB1.19 cells was analyzed by Western blotting. (C) The mRNA level of IRF7 in hFOB1.19, Saos-2, U2OS, and MNNG-HOS cells upon treatment with different concentrations of DAC and TSA was analyzed by real-time qPCR. (D) Representative methylation-specific polymerase chain reaction (PCR) at IRF7 promoter in the presence or absence of DAC treatment. *P < 0.05; **P < 0.01; ***P < 0.001.