Figure 6.

Rab31 knockdown inhibits tumor growth in nude mice. (A) In vivo fluorescence imaging of nude mice showed the fluorescence intensity of the tumors in the left and right flanks. (B) Tumor growth was monitored, and the volume was measured every 2 days with calipers. The growth curve of tumors was shown (left). The nude mice and tumors were photographed after the nude mice were euthanized (right). (C) H&E staining of transplanted tumor was used to detect the integrity of the tumor envelope. The arrows indicate the tumor envelope. (D) Immunohistochemical staining of Rab31 and MAPK6 in transplanted tumors was shown. ^*P<0.05, ^**P <0.01, ^***P<0.001.