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. 2022 Jan 1;18(1):242–260. doi: 10.7150/ijbs.66506

Figure 8.

Figure 8

LBH overexpression suppressed VEGFA secretion from both NPC cells and HUVECs, and downregulated VEGFA/VEGFR2 signaling in NPC xenograft tumors. (A) Secreted VEGFA in the cell supernatants of SUNE1 cells and HUVECs treated with NPC exosomes, and in the cell supernatants of stable LBH overexpressing SUNE1 cells or HUVECs were measured by ELISA (***p<0.001 vs. Control; ^^^p<0.001 vs. Lv5NC). (B) Protein expression of LBH, p-VEGFR2, VEGFR2, p-AKT, AKT, p-P38, and P38 in tumor xenografts constructed with CNE2-Lv5NC, CNE2-LBH, SUNE1- Lv5NC, or SUNE1-LBH cells (***p<0.001 vs. Lv5NC). (C) Schematic summary of the LBH/CRYAB-mediated, VEGFA-VEGFR2 signaling responsible for modulating the migration/invasion and EMT process of NPC cells by autocrine signaling and for modulating the proliferation, migration and angiogenesis of HUVECs by paracrine signaling in the NPC microenvironment.