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. 2022 Jan 1;18(1):441–458. doi: 10.7150/ijbs.64187

Figure 5.

Figure 5

Minocycline preserves BBB integrity through inhibiting the AQP4 expression. (A) Abridged general view of drug administrations and experiment protocol to further explore the specific role of AQP4 after TBI. (B-C) Representative western blot analysis and quantification of AQP4 to verify the effects of AQP4 agonist and inhibitor after TBI. n=3 per group. (D) Representative western blot analysis of tight junction proteins (ZO-1, Occludin and Claudin-5) and MMP-9 in six independent groups described above. (E-H) Quantification of tight junction proteins and MMP-9. n=3 per group. All data represent the mean ± SEM. *P < 0.05, **P < 0.01 vs. the indicated group. # P < 0.05, ## P < 0.01 vs. the TBI group.