Figure 7.
The model of XBP1 deficiency in cartilage is associated with various tissue diseases. (A)XBP1 deficiency in cartilage leads to differences in various of secreted factors and complete transcriptome RNA of Chondrocytes, including all kinds of ncRNAs with differential expression and regulatory profiles 63. (B) The coordinated regulation between different tissues and organs is performed by various of secreted factors and full spectrum of transcriptome RNA, including mRNA and ncRNAs. The differential ncRNAs and secreted factors caused by XBP1 deficiency in chondrocyte may cause abnormalities in different signaling pathways of different organs and tissues through blood and body fluid circulation 64, 65, including Wnt, insulin, AMPK, and adipocytokine signal pathway. Then these differential signal pathways lead to abnormalities in the functions of other different tissues and organs, including the nervous system, heart, bones, thyroid, and intestines. Such abnormalities, in turn, result in many kinds of different diseases. The black marks in the joint cavity represent various different ncRNAs and secreted proteins from chondrocytes.