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. 2022 Jan 1;18(1):65–81. doi: 10.7150/ijbs.62106

Figure 7.

Figure 7

The comparison of Id1 and E2F4 expression in HBV-related HCC and schematic representation of the anti-HBV role of Id1. (A) The protein expression of E2F4, Id1 and HBc in TT and ANTT from 25 cases HBV-related HCC patient were tested by western blotting with β-actin used as the control protein. The right bar graph is the corresponding statistical figure. *P <0.05, **P < 0.01. n=25. (B) The conservatism of nt1758-1766 site sequence among four common HBV genotypes was shown. (C) HBV DNA were detected Id1 and E2F4 showed pan-genotypic antagonistic and synergistic effects on HBV respectively. *P < 0.05 and **P < 0.01. n = 5. (D) Schematic representation of E2F4-induced activation of HBV transcription and the anti-HBV role of Id1. NTCP, sodium taurocholate cotransporting polypeptide; rcDNA; relaxed circular DNA, cccDNA, covalently closed circular DNA; pgRNA, pregenomic RNA; ER, endoplasmic reticulum; Golgi, Golgi apparatus.