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Schematic representation of RIP3 blockade in preventing immune-mediated hepatitis. RIP3 kinase inhibition promotes the hepatic accumulation of MDSCs by CXCL1-CXCR2 axis and other unknown factors. Accumulated MDSCs mediate the hepatoprotective effect of GSK872 by reducing the frequencies of Th17 cells and macrophages but increasing those of Treg cells.
