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. 2022 Jan 1;18(1):140–153. doi: 10.7150/ijbs.65676

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SLPI suppressed tumor growth and tumorigenesis in vivo. A. SLPI up-regulation inhibited growth of SK-Hep-1 xenograft tumors (n = 6 in each group). These tumors were formed by injection of SK-Hep-1 cells overexpressing SLPI or carrying a negative control. B. Tumor volumes were measured every 3 days. C. Average tumor weights of the xenografts were recorded. D. SLPI down-regulation promoted growth of BEL 7402 xenograft tumors (n = 6 in each group). These tumors were generated by injection of BEL 7402 cells with SLPI knockdown (sh_SLPI) or carrying a negative control (sh_NC). E. Tumor volumes were measured every 3 days. F. Average tumor weights of the xenografts were recorded.*P < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.