TABLE 2.
Prevalence of clinical findings in cats staged as IRIS 1 or 2 before and at the end of each diet intervention a
| LP‐LP dry (months 1‐17) | MP‐MP dry‐wet (months 22‐43) | |||
|---|---|---|---|---|
| (Month 2) | (Month 17) | (Month 21) | (Month 43) | |
| Age, median (min, max), years | 4.9 (2.4‐9.8) | 7.0 (3.7‐11.1) | 7.3 (4.0‐11.4) | 9.2 (5.9‐13.3) |
| BCS 4‐5 | ND | 2 | 1 | 12 |
| BCS 6‐7/8‐9 | ND | 9/6 | 8/7 | 3/0 |
| IRIS 1 CKD | 1/19 | 6/17 | 5/16 | 11/15 |
| Adult | 0 | 4 | 3 | 7 |
| Senior (≥9 years) | 1 | 2 | 2 | 4 |
| IRIS 2 CKD | 18/19 | 11/17 | 11/16 | 4/15 |
| Adult | 15 | 6 | 6 | 0 |
| Senior (≥9 years) | 3 | 5 | 5 | 4 |
| Systolic hypertension >160 mm Hg b | 6/19 | 4/17 | 4/16 | 4/15 |
| IRIS 1 | 0 | 0 | 2 | 4 |
| IRIS 2 | 6 | 4 | 2 | 0 |
| Borderline proteinuria b , c | 2/19 | 4/17 | ND | 4/15 |
| IRIS 1 | 0 | 1 | 1 | |
| IRIS 2 | 2 | 3 | 3 | |
| Increased renal echogenicity | 4/19 | 5/17 | ND | 7/15 |
| IRIS 1 | 1 | 1 | 1 | |
| IRIS 2 | 3 | 4 | 6 | |
| RIM sign | 18/19 | 16/17 | ND | 15/15 |
| IRIS 1 | 1 | 1 | 5 | |
| IRIS 2 | 17 | 15 | 10 | |
| Altered shape/size | 1/19 | 1/17 | ND | 4/15 |
| IRIS 1 | 0 | 0 | 1 | |
| IRIS 2 | 1 | 1 | 3 | |
| Reduced cortico‐medullar definition | 2/19 | 2/17 | ND | 5/15 |
| IRIS 1 | 0 | 0 | 0 | |
| IRIS 2 | 2 | 2 | 5 | |
| Renoliths‐ureteroliths | 2‐0/19 | 2‐0/17 | ND | 1‐1/15 |
| IRIS 1 | 0 | 0 | 0 | |
| IRIS 2 | 2 | 2 | 2 | |
| Uroliths | 0/19 | 6/17 | ND | 1/15 |
| IRIS 1 | 0 | 0 | 0 | |
| IRIS 2 | 0 | 6 | 1 | |
| Total hypercalcemia, >11.8 mg/dL | 0/19 | 5/17 | 2/16 | 0/15 |
| IRIS 1 | 0 | 0 | 0 | 0 |
| IRIS 2 | 0 | 5 | 2 | 0 |
| Ionized hypercalcemia, >5.41 mg/dL | 0/19 | 13/17 | 7/16 | 3/15 |
| IRIS 1 | 0 | 1 | 1 | 2 |
| IRIS 2 | 0 | 12 | 6 | 1 |
| CaOx RSS > 12.5 | ||||
| In cats without renoliths | 0/17 | ND | ND | 0/12 |
| In cats with renoliths | 0/2 | 2/2 | ND | 0/2 |
| MAP RSS > 2.5 | ||||
| In cats without renoliths | 2/17 | ND | ND | 0/12 |
| In cats with renoliths | 1/2 | 0/2 | ND | 0/2 |
Abbreviations: BCS, body condition score; CaOx, calcium oxalate; IRIS, International Renal Interest Society; LP‐LP, low protein low P; ND, not determined; MAP, magnesium ammonium phosphate; MP‐MP, moderate protein moderate P; RSS, relative supersaturation; UAC, urine albumin to creatinine ratio; UPC, urine protein to creatinine ratio.
a
IRIS stage based on serum creatinine and SDMA and substaged by UPC, systolic blood pressure, and renal imaging.
b
Number of cases reported during each dietary intervention.
c
Based on UAC at prefeed (≥30 and <300 in 2 cats) 22 and on UPC (0.2‐0.3) during the study.