TABLE 3.
Biochemistry variables in cats with early CKD fed a low protein, low P (LP‐LP) and subsequently a moderate protein, moderate P (MP‐MP) diet
| Prefeed | LP‐LP dry (months 1‐18) | LP‐LP dry‐wet (months 19‐21) | MP‐MP dry‐wet (months 22‐43) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Item [reference] | Mean 95% CI | Time a | Mean | 95% CI | P b | Time a | Mean | 95% CI | P c | Time a | Mean | 95% CI | P b |
| Albumin, g/dL [25−45] | 34.8 (33.3, 36.3) | +1 | 32.6 | 31.1, 34.3 | <.001 | +3 | 29 | 27.7, 30.3 | .003 | +1 | 29.8 | 28.4, 31.3 | .14 |
| +3 | 31.1 | 29.7, 32.6 | <.001 | +3 | 31.4 | 29.9, 32.9 | <.001 | ||||||
| +6 | 31.8 | 30.3, 33.3 | .14 | +9 | 31.6 | 30.1, 33.2 | <.001 | ||||||
| +11 | 29.6 | 28.2, 31 | <.001 | +16 | 31.1 | 29.6, 32.6 | .007 | ||||||
| +17 | 30.3 | 28.9, 31.8 | <.001 | +22 | 30.9 | 29.4, 32.4 | .04 | ||||||
| Creatinine, mg/dL [0.91‐2.02] | 2.03 (1.87, 2.2) | +1 | 1.84 | 1.7, 2 | .001 | +3 | 1.73 | 1.59, 1.88 | .74 | +1 | 1.49 | 1.37, 1.62 | <.001 |
| +3 | 1.62 | 1.49, 1.76 | <.001 | +3 | 1.49 | 1.36, 1.62 | 1 | ||||||
| +6 | 1.6 | 1.47, 1.73 | <.001 | +9 | 1.41 | 1.3, 1.53 | .33 | ||||||
| +11 | 1.64 | 1.51, 1.78 | <.001 | +16 | 1.47 | 1.35, 1.6 | 1 | ||||||
| +17 | 1.68 | 1.54, 1.83 | .005 | +22 | 1.39 | 1.28, 1.51 | .11 | ||||||
| BUN, mg/dL [7.00‐27.7] | 24 (22.4, 25.7) | +1 | 23.8 | 22, 25.7 | .96 | +3 | 22.2 | 20.6, 23.8 | .07 | +1 | 24 | 22.2, 26.1 | .01 |
| +3 | 20.6 | 19.1, 22.3 | <.001 | +3 | 22.8 | 21, 23.5 | .38 | ||||||
| +6 | 19.3 | 17.9, 20.9 | <.001 | +9 | 22.5 | 20.7, 24.4 | .13 | ||||||
| +11 | 19.6 | 18.1, 21.2 | <.001 | +16 | 21.8 | 20.1, 23.6 | .004 | ||||||
| +17 | 20.9 | 19.2, 22.6 | <.001 | +22 | 23 | 21.2, 25 | .58 | ||||||
| SDMA, μg/dL | 14.2 (12.5, 16.2) | +1 | 15.5 | 13.2, 18.1 | .22 | +3 | 14.2 | 12.4, 16.3 | .01 | +1 | 10.6 | 9.03, 12.5 | <.001 |
| +3 | 12.9 | 11, 15 | .008 | +3 | 11.3 | 9.55, 13.2 | .95 | ||||||
| +6 | 11.2 | 9.57, 13.1 | <.001 | +9 | 11.8 | 9.99, 13.9 | .48 | ||||||
| +11 | 11.9 | 10.1, 13.9 | <.001 | +16 | 13.1 | 11.1, 15.4 | .005 | ||||||
| +17 | 16.4 | 13.9, 19.2 | .93 | +22 | 11 | 9.35, 13 | 1 | ||||||
| P, mg/dL [2.79‐6.88] | 4.15 (3.88, 4.46) | +1 | 4.43 | 4.15, 4.74 | .06 | +3 | 4.68 | 1.4, 1.62 | .88 | +1 | 4.34 | 4.03, 4.68 | .05 |
| +3 | 4.99 | 4.65, 5.33 | .002 | +3 | 4.19 | 3.91, 4.53 | .92 | ||||||
| +6 | 4.96 | 4.65, 5.33 | .002 | +9 | 4.25 | 3.94, 4.59 | 1 | ||||||
| +11 | 4.37 | 4.12, 4.71 | 1 | +16 | 4.37 | 4.09, 4.71 | 1 | ||||||
| +17 | 4.59 | 4.25, 4.93 | .94 | +22 | 4.28 | 3.97, 4.59 | 1 | ||||||
| iCa, mg/dL [4.85‐5.41] | 5.01 (4.85, 5.17) | +1 | 5.01 | 4.73, 5.31 | 1 | +3 | 5.47 | 5.31, 5.65 | .005 | +1 | 5.27 | 4.95, 5.6 | .02 |
| +3 | ND | +3 | 5.16 | 4.84, 5.49 | .95 | ||||||||
| +6 | ND | +9 | 5.31 | 5.98, 5.65 | 1 | ||||||||
| +11 | ND | +16 | 5.08 | 4.78, 5.41 | .68 | ||||||||
| +17 | 5.71 | 5.38, 6.07 | <.001 | +22 | 5.19 | 4.88, 5.52 | .98 | ||||||
| Ca × P, mg2/dL2 | 38 (34.9, 41.4) | +1 | 42.8 | 39.1, 46.9 | .002 | +3 | 47.8 | 43.6, 52.4 | .14 | +1 | 42.6 | 38.7, 47 | .02 |
| +3 | 47.4 | 43.4, 51.8 | .06 | +3 | 43.2 | 39.2, 47.6 | 1 | ||||||
| +6 | 50.2 | 45.9, 54.9 | <.001 | +9 | 41.9 | 38.1, 46.1 | 1 | ||||||
| +11 | 45.3 | 41.4, 49.6 | .64 | +16 | 41.5 | 34.1, 50.5 | 1 | ||||||
| +17 | 51.4 | 48.9, 56.5 | <.001 | +22 | 41.5 | 37.7, 45.7 | 1 | ||||||
Abbreviations: BUN, blood urea nitrogen; CI, confidence interval; CKD, chronic kidney disease; ND, not determined; P, phosphorus; SDMA, symmetric dimethylarginine.
a
Months on diet with LP‐LP dry, LP‐LP dry‐wet, and MP‐MP dry‐wet. Prefeed variables measured at month −2.
b
For LP‐LP dry and MP‐MP dry‐wet, comparisons vs +1 are performed; P‐values at +1 denote changes from prefeed and from LP‐LP dry‐wet (+3), respectively.
c
For LP‐LP dry‐wet, comparison vs LP‐LP dry (+17) is performed.