. 2021 Sep 21;35(6):2797–2811. doi: 10.1111/jvim.16263

TABLE 4.

Serum vitamin D and urine variables in cats with early CKD fed a low protein, low P (LP‐LP) and subsequently a moderate protein, moderate P (MP‐MP) diet

	Prefeed dry	LP‐LP dry (months 1‐18)				MP‐MP dry‐wet (months 22‐43)
	Mean (95% CI) ^a	Time ^b	Mean	95% CI	P ^c	Time ^b	Mean	95% CI	P ^c
Calcidiol 25(OH)D3, nmol/L	ND	+3	121	98.5, 148		+3	114	92.2, 142
		+6	116	94.9, 143	1	+9	105	84.4, 130	.86
		+11	89.8	73.2, 111	<.001	+16	99.6	80.3, 126	.46
		+17	101	82.1, 125	.17	+22	107	86.1, 134	.97
C3‐Epi‐25(OH)D3, nmol/L	ND	+3	25.3	20.9, 30.6		+3	19.4	15.9, 23.7
		+6	25.9	21.4, 31.4	1	+9	25.7	21.1, 31.5	.001
		+11	22.7	18.7, 27.4	.49	+16	18.9	15.4, 23.1	1
		+17	20.4	16.7, 24.8	.02	+22	17.7	14.4, 21.7	.76
Calcitriol 1,25 (OH)₂D, pmol/L	ND	+3	20.3	14.8, 27.7		+3	35.3	25.3, 49.4
		+6	21.2	15.5, 28.9	1	+9	27.1	19.9, 36.8	.15
		+11	14.3	9.52, 21.6	.14	+16	40.2	9.6, 54.7	.83
		+17	28.6	20.3, 40.3	.05	+22	25.7	17.8, 37.1	.14
24,25(OH)₂D2, nmol/L	ND	+3	29.8	22.1, 40.2		+3	25.2	18.4, 34.6
		+6	22.8	6.9, 30.8	.14	+9	28.9	21, 39.6	.85
		+11	15.2	11.3, 20.5	<.001	+16	24.8	18.1, 34.1	1
		+17	16.2	11.9, 22.1	<.001	+22	29.3	21.2, 40.5	.79
Urine specific gravity	1.037 (1.033, 1.044)	+3	1.042	1.035, 1.049		+3	1.03	1.023, 1.037
		+6	1.043	1.036, 1.05	1	+9	1.03	1.023, 1.038	1
		+11	1.041	1.034, 1.048	1	+16	1.036	1.028, 1.043	.4
		+17	1.036	1.03, 1.04	.42	+22	1.039	1.032, 1.047	.05
Urine pH	6.31 (5.87, 6.78)	+3	5.94	5.36, 6.59		+3	5.74	5.14, 6.4
		+6	7.67	6.94, 8.49	<.001	+9	6.59	5.88, 7.38	.1
		+11	7.16	6.45, 7.94	.004	+16	6.64	5.95, 7.41	.06
		+17	7.36	6.61, 8.18	<.001	+22	6.81	6.06, 7.65	.02

Abbreviations: CI, confidence interval; CKD, chronic kidney disease; ND, not determined; P, phosphorus.

^{^a}

Urine parameters measured 2 months before feeding LP‐LP dry.

^{^b}

Months on diet with LP‐LP dry and MP‐MP dry‐wet. Prefeed variables measured at month‐2.

^{^c}

Within each dietary intervention, P‐values denote changes from levels after 3 months (+3) on each diet.