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. 2021 Dec 8;11:719140. doi: 10.3389/fonc.2021.719140

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Copyright © 2021 Perincheri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of tumor microenvironment in lymphomas. (A) Benign lymph node with a germinal center containing tangible body macrophages (arrow). (B) Follicular lymphoma with neoplastic follicle. (C) Diffuse large B cell lymphoma showing tissue effacement by large, neoplastic cells with very few admixed small lymphocytes. (D) Classic Hodgkin lymphoma showing rare Reed-Sternberg cells (arrow) in a background of small lymphocytes and histiocytes with fibrosis.