Nooh 2018.
Methods | Randomised controlled trial |
Participants | Location: 1 hospital in Egypt Timeframe: September 2012 to August 2016 Eligibility criteria: women with a singleton pregnancy in the cephalic presentation planned to have a cesarean section at 38 weeks' gestation of pregnancy or beyond Exclusion criteria: women with multiple gestations or any obstetric disorders (such as pre‐eclampsia, antepartum haemorrhage, intrauterine growth restriction, breech presentation etc) or medial disorders (such as asthma, hypertension, diabetes, intrauterine infection, etc.) or history of smoking or peptic ulceration were excluded |
Interventions | Intervention: 3 doses of 8 mg/2mL of dexamethasone administered intramuscularly 8 hours apart, 24 hours after the last dose (n = 636) Placebo: in the placebo group: usual care (without antenatal steroids) (n = 636) |
Outcomes | Primary: admission to NICU with respiratory morbidity Secondary: incidence of TTN, RDS and need for mechanical ventilation |
Notes | Additional outcomes including neonatal death and neonatal sepsis were reported on. Funding source of study: "The authors received no financial support for the research, authorship, or publication of this article." Declarations of interest: "The authors report no conflicts of interest." We contacted the trial authors in January 2021 to ask for more information about their trial registration. Awaiting reply. Not included in 2021 update because of lack of response from trial authors regarding our trustworthiness criteria (trial published since 2010 without prospective registration) |