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. 2021 Dec 22;2021(12):CD006614. doi: 10.1002/14651858.CD006614.pub4

Sadiq 2019.

Methods Design: RCT
Setting: Kahuta Research Laboratories (KRL), Hospital, Islamabad, Pakistan
Participants Inclusion criteria: pregnant women with singleton alive fetus between gestational age of 37 + 6 to 38 + 6 weeks, admitted for elective LSCS under spinal anaesthesia, gestational age confirmed by the date of last menstrual period and in cases of unsure of dates, by the first trimester dating scan, patients with uncomplicated gestational diabetes mellitus, pregnancy induced hypertension, anaemia and asthma
Exclusion criteria: women with type 1 or 2 DM, chronic hypertension, preeclampsia, pre‐labour rupture of membranes, multiple pregnancies, infections including tuberculosis, congenital anomalous fetus, intrauterine growth restriction (IUGR) fetuses and emergency LSCS or operated under general anaesthesia
Number randomised: 320 (A 158, B 162)
Number analysed: 304 (A 152, B 152)
Interventions Intervention (n = 158): one course of dexamethasone within 7 days of LSCS. Two doses of 12 mg, each given intramuscularly to the pregnant woman, 12 hours apart
Control (n = 162): no treatment
Outcomes
  • Apgar score

  • Neonatal  resuscitation

  • Admission to NICU

  • TTN

  • RDS

  • Supplementary oxygen

  • Mechanical ventilation

  • Blood sugar monitoring

  • Length of stay in NICU

Notes Dates of study: September 2017 to September 2019
Funding sources: "Grant support and financial disclosure ‐  NIL"
Declarations of interest: "Authors declared no conflict of interest"
We contacted the trial authors in March 2021 to ask for more information the prospective trial registration status. The trial authors replied "a clinical protocol was designed before conducting the study that was presented to the institutional review committee. But the clinical trial was not registered except with the local hospital body and after reviewing they gave us the ethical permission and approval for conducting study."
Not included in 2021 update because of lack of response from trial authors regarding our trustworthiness criteria (trial published since 2010 without prospective registration)

BPD: bronchopulmonary dysplasia
CPAP: continuous positive airway pressure
CS: caesarean section
DM: diabetes mellitis 
ECMO: extracorporeal membrane oxygenation
El‐LSCS: lower (uterine) segment caesarean section
IM: intramuscular
IUGR: intrauterine growth restriction
LMP: last menstrual period
NICU: neonatal intensive care unit
PROM: premature rupture of membranes
RDS: respiratory distress syndrome
TTN: tachypnoea of the newborn