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. 2021 Dec 22;2021(12):CD006614. doi: 10.1002/14651858.CD006614.pub4

IRCT20120918010876N4 2018.

Study name  
Methods Design: RCT
Setting: Mahdieh hospital, Tehran, Iran
Participants Inclusion criteria: women with singleton pregnancy with elective cesarean section at week 37 to 38 weeks and 6 days will enrol in the study
Exclusion criteria: multiple pregnancies, fetus with major congenital anomalies, fetus with other medical or midwifery conditions that give birth earlier, receive dexamethasone or betamethasone during pregnancy, maternal severe hypertension, maternal history of peptic ulcer, and evidences of intrauterine infection
Target sample size: 220
Interventions Treatment group: intramuscular injection of 12 mg betamethasone in two doses between 24 hours, 48 hours before cesarean section
Control group: cesarean section without betamethasone injection
Outcomes Neonatal respiratory outcomes
  • Need for CPAP or nasal cannula with high‐current continuous

  • Need for continuous high‐pressure oxygen with FiO2 more than 30%

  • Need for mechanical ventilation

  • Need for ECMO or resuscitation at birth

  • Respiratory distress syndrome

  • Neonatal tachypnea

  • Apnoea

  • Bronchopulmonary dysplasia

  • Pneumonia

  • Use of surfactant

  • Need for care in the NICU

  • Duration of hospitalisation

Starting date  
Contact information  
Notes Study dates: registered 11 January 2018
Funding sources: "Shahid Beheshti University of Medical Sciences"
Declarations of interest: not reported
We contacted the investigators on 8 March 2020 to ask if they had any outcome data we could include.
Contact details: z.joshaghani@hotmail.com