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. 2021 Dec 21;13(1):22. doi: 10.1038/s41419-021-04462-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Representative images were shown to exhibit the transfected effects of Caki-1 cells with the vector or circPPP6R3-overexpressing plasmids. B The overexpressing efficiency of circPPP6R3 was detected in Caki-1 cells. C, D MTS assay and colony formation assay were performed to examine the proliferation of Caki-1 cells. E, F Transwell assay, invasion assay, and wound-healing assay were used to detect the migrative and invasive abilities of Caki-1 cells. G The images of the nude mice subcutaneously injected with the vector or circPPP6R3-overexpressed Caki-1 cells were shown. H The subcutaneous tumors of stably circPPP6R3-overexpressed or vector group were shown. I The growth curves of the subcutaneous tumors were performed by measuring the tumor volumes. J The weight of the subcutaneous tumors was measured. K Representative IHC images of the subcutaneous tumors stained with Ki67 in circPPP6R3-overexpressed or vector group were shown. L Representative HE images of the metastatic tumors in the liver in the hematogenous metastasis model were shown.