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Proposed schema of the a-globin augmentation of plasmin activity. Plasminogen (PLG) circulates in a reversible complex with histidine rich glycoprotein (HRG), which is a competitive inhibitor, which can encounter the α-globin chain of hemoglobin (α-globin). In response to fibrin endothelial cells release tissue plasminogen activator (tPA) which than activated plasminogen, which is bound to the α-globin chain, and causes increased plasmin activity.
