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. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: J Trauma Acute Care Surg. 2022 Jan 1;92(1):159–166. doi: 10.1097/TA.0000000000003410

Table 2.

Selected Proteomics and enzymes from the Coagulation and Fibrinolytic Cascades

		QConCat Analysis (Median (Q1–Q3)
Protein		Healthy Controls	Hyperfibrinolysis	Shutdown	Physiologic
Hemoglobin, alpha subunit		0.3 (0.2–0.7)	4.5 (1.3–6.6)^**	1.1 (0.48–3.5)^**	0.8 (0.6–1.1)^**
Hemoglobin, beta subunit		1.5 (1.2–4.2)	9.1 (2.8–20.4)^**	4.7 (2.4–13.4)	4.5 (2.7–7.9)
Haptoglobin		28.3(16.2–36.5)	22.8 (9.4–30.5	26.1 (23.0–27.9)	29.6 (16.3–42.4)
		ELISA Analysis
Alpha 2-antiplasmin (μg/ml)		1122.4±196.7	890.9±217.1	1367.6±251.8	921.2±151.5
Antithrombin III (μg/ml)		526.5±44.0	253.2±44.7^*	464.8±35.3	382.4±47.3
Thrombin(ng/ml)		144.4±12.1	133.5±13.8	153.5±27.3	134.2±15.3
Plasminogen (μg/ml)		1127.8±188.2	529.6±120.8^*	995.2±228.1	1187.2±116.7
Plasmin anti-plasmin (ng/ml)		0.5±0.05	415.7±199.0^*	4.8±3.8	2.8±1.0
Thrombin anti-Thrombin (ng/ml)		4.4±0.6	9.0±1.5^*	6.4±0.7	8.5±1.4^*
tPA	Activity (U/ml)	0.002±0.001	0.89±0.2^*	0.001±0.001	0.03±0.01^*
tPA	Total (ng/ml)	3.6±0.8	10.9±2.3^*	14.9±3.1^*	10.3±2.1^*
PAI-1	Activity (U/ml)	4.0±1.6	1.9±0.1	79.3±26.6^*	5.0±2.0
PAI-1	Total (ng/ml)	7.6±2.6	8.41±2.3	115.±35.2^*	13.0±3.8
tPA:PAI-1 (ng/ml)		5.8±1.3	15.4±3.7^*	24.0±4.9^*	16.5±3.4^*

^**

p<0.01 from Healthy Controls;

^*

p<0.05 from Healthy Controls