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. Author manuscript; available in PMC: 2022 Dec 20.
Published in final edited form as: Dev Cell. 2021 Nov 30;56(24):3364–3379.e10. doi: 10.1016/j.devcel.2021.11.009

Figure 7: Cell cycle-regulated ER membrane biogenesis by CTDNEP1 dephosphorylation of lipin 1 allows chromosome movements necessary for biorientation.

Figure 7:

When CTDNEP1 is absent, phosphorylation of lipin 1 by mTOR and other kinases prevails and leads to decreased lipin 1 stability and an increased flux in de novo FA synthesis towards ER membrane biogenesis in interphase. Excess ER membranes inherited by mitotic cells contribute to higher cytoplasmic viscosity and dampened chromosome motions. The lack of chromosome motions limits mitotic error correction, leading to micronuclei formation.