Table 2.
Summarized toxicities data for TCb regimens.
| Adverse events | AEs No./No. (%) | p value | |
|---|---|---|---|
| TCb group | A&T group | ||
| Haematologic toxicity (Grade 3/4) | |||
| Neutropaenia | 384/523 (73.4) | 425/518 (82.0) | <0.001** |
| Febrile neutropaenia | 3/322 (0.9) | 30/320 (9.4) | <0.001** |
| Leukopenia | 315/476 (66.2) | 371/474 (78.3) | <0.001** |
| Anaemia | 35/476 (7.4) | 7/474 (1.5) | <0.001** |
| Thrombocytopaenia | 26/523 (5.0) | 10/518 (1.9) | 0.007** |
| Non-hematological toxicity | |||
| Anorexia/Nausea (Grade 3/4) | 7/476 (1.5) | 16/474 (3.8) | 0.05* |
| Vomiting (Grade 3/4) | 4/369 (1.1) | 10/364 (2.7) | 0.10 |
| Diarrhea/Abdominal pain (Grade 3/4) | 5/322 (1.6) | 13/320 (4.1) | 0.05* |
| Alopecia (Grade 3/4) | 27/154 (17.5) | 56/154 (36.4) | <0.001** |
| ALT/AST elevation | 74/523 (14.1) | 75/518 (14.5) | 0.879 |
| Peripheral neuropathy | 46/201 (22.9) | 62/198 (31.3) | 0.06 |
| Fatigue | 17/154 (11.0) | 21/154 (13.6) | 0.488 |
| Myalgia/arthralgia | 17/201 (8.5) | 28/198 (14.1) | 0.07 |
| ST-T changes in ECG | 35/201 (17.4) | 47/198 (23.7) | 0.11 |
NS not shown.