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. 2021 Dec 8;8:801228. doi: 10.3389/fnut.2021.801228

Table 2.

Subgroup analysis for high vs. low salt intake and the risk of gastric cancer.

Group RR and 95%CI P-value Heterogeneity (%) P-value for heterogeneity Ratio between subgroups P-value for interaction test
Country
US or Europe 1.16 (0.96–1.40) 0.130 0.0 0.706 0.88 (0.68–1.13) 0.315
Asia 1.32 (1.11–1.55) 0.001 69.0 0.001
Gender
Men 1.10 (1.03–1.17) 0.002 0.0 0.812 1.01 (0.88–1.16) 0.898
Women 1.09 (0.96–1.23) 0.171 0.0 0.750
Outcomes
GC incidence 1.14 (1.05–1.25) 0.003 25.0 0.222 0.60 (0.39–0.93) 0.022
GC mortality 1.89 (1.24–2.89) 0.003 50.6 0.108
Follow-up duration (years)
≥ 10.0 1.38 (1.12–1.69) 0.002 57.6 0.015 1.25 (1.01–1.55) 0.037
<10.0 1.10 (1.04–1.16) <0.001 0.0 0.692
Adjusted educational
Yes 1.23 (1.06–1.42) 0.006 0.0 0.866 0.95 (0.76–1.18) 0.626
No 1.30 (1.10–1.54) 0.003 65.0 0.002
Adjusted BMI
Yes 1.32 (1.03–1.69) 0.026 79.0 0.003 1.07 (0.81–1.43) 0.630
No 1.23 (1.07–1.43) 0.004 22.2 0.246
Adjusted alcohol
Yes 1.21 (1.01–1.46) 0.036 65.9 0.012 0.93 (0.72–1.20) 0.581
No 1.30 (1.09–1.55) 0.003 28.1 0.214
Adjusted smoking
Yes 1.22 (1.04–1.42) 0.015 55.9 0.026 0.92 (0.70–1.22) 0.583
No 1.32 (1.04–1.66) 0.020 48.2 0.103
Adjusted PA
Yes 1.24 (1.01–1.52) 0.038 72.7 0.005 0.98 (0.75–1.26) 0.856
No 1.27 (1.09–1.49) 0.002 19.6 0.275

RR, relative risk; CI, confidence interval; GC, gastric cancer; BMI, body mass index; PA, physical activity.