Table 4:
Multivariable Cox Model Assessing Relationship between Right Heart Indices and Incident Cardiovascular Events
| Multivariable | HR (95% CI) | p | Points |
|---|---|---|---|
| RA reservoir strain <31% | 1.67 (1.12–3.89) | 0.004 | 1 |
| RA volume index >27 ml/m2 (F) or >32 ml/m2 (M) | 1.98 (1.02–4.15) | 0.02 | 1 |
| RV global longitudinal strain >−18% | 1.73 (1.08–3.03) | 0.008 | 1 |
| RVSP >40 mmHg | 3.26 (1.54–7.34) | <0.001 | 2 |
| RA pressure ≥8 mmHg | NS | NS | |
| RV end-diastolic area >25 cm2 | NS | NS | |
| ≥Moderate tricuspid regurgitation | NS | NS | |
| LV GLS, per unit increment | 1.14 (1.06–1.29) | 0.001 | |
| LV mass index per 5 g/m2 increment | 1.06 (1.01–1.15) | 0.006 | |
| Right Heart Hemodynamic Score (RHHS) | 5 |
RA: Right atrium; RV: Right ventricle; RVSP: Right ventricular systolic pressure; PA: Pulmonary artery; HR: Hazard ratio; CI: Confidence interval
A RHHS was created by assigning 0.5 points for every 1 unit increase in HR for each of 4 right heart indices in the model. The total score was then computed for each patient by summing up the points for each of the abnormal indices present in each patient. The composite score ranged from 0 to 5.
NS denote variables that were not statistically significant.