Table 5:
Univariable Cox Model for Predictors of Incident Cardiovascular events
| HR (95% CI) | p | |
|---|---|---|
| COA mean gradient, per 1 mmHg | 1.26 (0748–2.54) | 0.5 |
| Aortic mean gradient, per 1 mmHg | 1.08 (0.91–1.12) | 0.3 |
| LV GLS, per unit increment | 0.91 (0.85–0.97) | 0.008 |
| LV mass index, per 5 g/m2 | 1.11 (1.02–1.25) | 0.009 |
| Atrial fibrillation | 2.02 (1.28–4.04) | <0.001 |
| Hypertension | 1.53 (1.18–2.33) | 0.01 |
| Coronary artery disease | 1.96 (1.24–4.16) | 0.004 |
| GFR, per 5-unit increment | 0.93 (0.84–1.01) | 0.06 |
| COA intervention* | 1.42 (0.81–1.83) | 0.5 |
| Age at time of COA repair, years | 1.03 (0.89–1.21) | 0.4 |
| LVOT intervention† | 0.92 (0.80–1.06) | 0.3 |
| Mitral valve intervention‡ | 1.31 (0.92–1.74) | 0.4 |
COA: Coarctation of aorta; LV: Left ventricle; GLS: Global longitudinal strain; GFR: Glomerular filtration rate; HR: Hazard rate; CI: Confidence interval, LVOT: Left ventricular outflow tract
COA intervention* denotes surgical COA repair or transcatheter intervention; LVOT intervention† denotes surgical resection of subaortic stenosis or aortic valve replacement; Mitral valve intervention‡ denotes mitral valve repair or replacement
The variables with p<0.25 were then used to create the multivariable Cox model in Table 6