Table 1.

Lead variants (p-value < 1×10⁻⁶) associated with hs-cTnT and hs-cTnI

rsID	Chr	Position (hg19)	Locus	Nearest gene(s)*	Relation to gene	A1/A2	AF	Beta (SE)	p-value	CADD
hs-cTnT (n=24,617)
rs10091864	8	71359103	8q13.3	NCOA2;TRAM1	intergenic	c/g	0.56	−0.07(0.008)	2.28E-19	0.22
rs9944895	18	60859974	18q21.33	BCL2	intronic	c/g	0.69	0.07(0.008)	1.05E-15	2.32
rs3737882	1	203034955	1q32.1	PPFIA4	intronic	c/g	0.82	0.06(0.010)	2.80E-09	12.64
rs28581409	8	71407059	8q13.3	TRAM1	intergenic	a/g	0.34	−0.05(0.008)	6.63E-09	0.62
rs75244633	4	119879588	4q26	SYNPO2	intronic	t/c	0.02	0.14(0.027)	1.44E-07	4.14
rs146737477	1	83763281	1p31.1	TTLL7	intergenic	a/g	0.03	−0.25(0.047)	1.65E-07	1.81
rs12506869	4	101000987	4q23	DDIT4L	ncRNA_intronic	a/g	0.26	−0.05(0.009)	2.13E-07	0.02
rs199460	17	44764775	17q21.31	NSF	intronic	a/c	0.74	−0.05(0.010)	3.07E-07	4.26
rs17618762	2	19846104	2p24.1	LINC00954;TTC32	intergenic	a/g	0.93	−0.09(0.017)	3.37E-07	0.58
rs13341435	17	64250605	17q24.2	APOH	intronic	a/g	0.06	0.08(0.016)	5.61E-07	3.86
rs1192168	11	65730945	11q13.1	SART1	intronic	t/g	0.50	0.04(0.007)	7.27E-07	0.18
rs9899998	17	29711014	17q11.2	NF1;RAB11FIP4	intergenic	a/g	0.06	−0.19(0.039)	8.22E-07	1.22
rs4922982	11	22237365	11p14.3	ANO5	intronic	t/c	0.31	−0.04(0.009)	9.21E-07	0.63
rs116819086	3	25449004	3p24.2	RARB	intronic	c/g	0.04	−0.24(0.048)	9.23E-07	0.10
hs-cTnI (n=14,336)
rs7915720	10	75774139	10q22.2	VCL;AP3M1	ncRNA_intronic	a/g	0.32	0.07(0.012)	5.51E-08	0.63
rs2915700	7	38984277	7p14.1	VPS41;POU6F2	intergenic	a/g	0.17	0.09(0.019)	7.97E-07	1.53
rs26742	5	16664769	5p15.1	MYO10	downstream	a/g	0.57	−0.06(0.012)	9.45E-07	0.71

Abbreviations

Chr: chromosome; AF_A1: allele frequency for allele 1; CADD: combined annotation dependent depletion score. This table presents the top 14 and 3 independent variants associated with hs-cTnT and hs-cTnI, respectively, at the significance level of p-value <1×10⁻⁶. Six studies were meta-analyzed using an inverse-variance-based fixed-effect approach. The statistics are based on the allele 1 (A1).

^*Nearest gene with a functional protein or RNA (e.g. anti-sense RNA) product that either overlaps with the sentinel variant, or for intergenic variants, the nearest genes up- and downstream, respectively.