TABLE 2.
Top differential pathways identified by GSEA of genes identified to be associated with quantitative BMI change or surgery group status differences
| Pathway | Overlap (BMI change; surgery group) | p value (BMI change; surgery group) | Proteins from BMI change or surgery group comparisons in each pathway |
|---|---|---|---|
| Signaling by interleukins | 128/201; 135/201 | 7.91e‐05; 4.97e‐04 | CCL11, IL1R1, IL23R, CNTFR, IL17RB |
| Adipogenesis | 16/31; 17/31 | 2.35e‐03; 9.33e‐03 | LEP, ADIPOQ, CNTFR |
| Cell adhesion molecules | 24/41; 17/41 | 4.67e‐03; 1.63e‐02 | NCAM1, CDH1, CNTN1, NEGR1, PDCD1LG2 |
| Cytokine signaling in immune system | 194/314; 189/314 | 5.19e‐03; 1.87e‐02 | NCAM1, CCL11, MET, GHR, IL1R1, TNFRSF17, PSPN, KIT, IL23R, CNTFR, IL17RB |
| MAPK family signaling cascades | 71/98; 60/98 | 6.36e‐03; 1.73e‐02 | NCAM1, MET, PSPN, KIT |
| Regulation of IGF transport and uptake by IGFBPs | 26/57; 25/57 | 6.83e‐03; 2.41e‐02 | IGFBP2, IGFBP1, SERPINC1, SPP1, SERPIND1 |
| Synthesis of GPI‐anchored proteins | 7/12; 7/12 | 8.81e‐03; 2.52e‐02 | LSAMP, CNTN4, NEGR1, CD109 |
| Complement cascade | 12/33; 16/33 | 1.44e‐02; 3.38e‐03 | CRP, C5a, SERPING1, FCN2, C5, C5b/6 complex |
| IL4 and IL13 signaling | 43/64; 45/64 | 1.76e‐02; 1.45e‐03 | CCL11, IL23R |
Protein examples for each pathway are shown only if the protein was among the 78 Bonferroni significant proteins according to Figure 1.
Abbreviations: GPI, glucose‐6‐phosphate isomerase; GSEA, gene set enrichment analysis; IGF, insulinlike growth factor; IGFBP, IGF binding protein; IL, interleukin; MAPK, mitogen‐activated protein kinase.