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. 2021 Jul 22;16(1):221–232. doi: 10.1038/s41396-021-01030-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Cold induced modifications to R. frigidialcoholis membrane. B Potential cold induced RNAi mechanisms in R. frigidialcoholis. Hollow arrows represent the miRNA and short rRFs (miRNA-like) mechanisms [105, 107], dashed arrows represent the rRFs derived from rDNA damage mechanism [115], double-dashed arrows represent the rFRs derived from erroneous rRNA mechanism resulting in rRNA synthesis inhibition [114]. C Cold induced switch in R. frigidialcoholis metabolism. A list of the abbreviations is included in the Supplementary material (Supplementary Table S5).