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. 2021 Jul 22;16(1):221–232. doi: 10.1038/s41396-021-01030-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Reconstructed electron transport chain (ETC) complexes of R. frigidialcoholis based on the KEGG genes annotation (top) and their relative differential gene expression profiles of the ETC subunits (bottom) of each triplicate culture. The genes with a significant (p < 0.05) differential expression of ≥1.5 log₂FC are indicated with a star in blue (overexpressed at 0 °C), or red (overexpression at 23 °C). For the heatmaps, blue indicates an overexpression of the gene at 0 °C, red indicates and overexpression of the gene at 23 °C, and white indicates genes that are not differentially expressed between the two temperatures.