Table 2:
Strength of associations between plasma GFAP, plasma NfL, brain volume, and cognition. Values represent standardized beta-weights with 95% confidence intervals shown in parentheses. Bolded values indicate associations that were statistically significant and in the same direction for both Cohort 1 and Cohort 2. Column (A) shows the outcome variable of the regression models. Cells in columns (B) and (D) represent the regression weights for separate models that included either GFAP (B) or NfL (D) as the lone plasma biomarker predictor. Cells in columns (C) and (E) represent the regression weights from a single regression model that included both GFAP and NfL simultaneously; therefore, cells in column (C) shows the unique associations of GFAP while adjusting for NfL, and cells in column (E) shows the unique associations of NfL while adjusting for GFAP.
| Predictor: GFAP | Predictor: NfL | |||||||
|---|---|---|---|---|---|---|---|---|
| GFAP Only | Both Biomarkers | NfL Only | Both Biomarkers | |||||
| Cohort 1 | Cohort 2 | Cohort 1 | Cohort 2 | Cohort 1 | Cohort 2 | Cohort 1 | Cohort 2 | |
| (A) | (B) | (C) | (D) | (E) | ||||
| Brain Volume a | ||||||||
| Total GM | .04 (−.17, .24) | −.31 (−.55, −.07)* | .04 (−.17, .24) | −.24 (−.54, .05) | −.01 (−.22, .21) | −.19 (−.48, .10) | −.01 (−.24, .21) | −.08 (−.39, .24) |
| Total WM | −.29 (−.48, −.10) ** | −.31 (−.57, −.06) * | −.31 (−.50, −.11)** | −.26 (−.58, .05) | .08 (−.14, .31) | −.02 (−.33, .29) | .12 (−.09, .33) | .10 (−.23, .44) |
| Frontal GM | .03 (−.22, .29) | −.24 (−.51, .03) | .04 (−.22, .08) | −.19 (−.52, .14) | −.04 (−.31, .24) | −.11 (−.42, .21) | −.04 (−.32, .24) | −.02 (−.37, .34) |
| Frontal WM | −.29 (−.49, −.08) ** | −.32 (−.58, −.06) * | −.30 (−.51, −.09)** | −.24 (−.56, .09) | .05 (−.19, .29) | −.06 (−.37, .25) | .09 (−.13, .31) | .05 (−.29, .39) |
| Temporal GM | −.01 (−.24, .22) | −.31 (−.57, −.06)* | −.01 (−.25, .22) | −.23 (−.55, .09) | .01 (−.24, .26) | −.18 (−.48, .13) | .02 (−.23, .27) | −.07 (−.41, .27) |
| Temporal WM | −.31 (−.52, −.11) ** | −.41 (−.67, −.16) ** | −.33 (−.53, −.12) ** | −.36 (−.69, −.03) * | .09 (−.15, .33) | −.13 (−.46, .19) | .13 (−.09, .35) | .04 (−.31, .38) |
| Parietal GM | −.06 (−.31, .19) | −.37 (−.61, −.13)** | −.05 (−.30, .20) | −.31 (−.60, −.02)* | −.11 (−.38, .15) | −.32 (−.60, −.03)* | −.11 (−.38, .17) | −.17 (−.48, .13) |
| Parietal WM | −.30 (−.53, −.06) * | −.35 (−.61, −.08) * | −.31 (−.55, −.07) * | −.35 (−.68, −.02) * | .04 (−.24, .31) | −.05 (−.38, .28) | .08 (−.18, .33) | .11 (−.24, .46) |
| Cognition b | ||||||||
| Executive Function | −.38 (−.67, −.09) * | −.41 (−.63, −.20) ** | −.38 (−.67, −.08) * | −.36 (−.62, −.10) ** | −.06 (−.40, .27) | −.47 (−.69, −.25)** | −.01 (−.33, .31) | −.24 (.50, .02) |
| Memory | −.30 (−.62, .02) | −.37 (−.60, −.13)** | −.31 (−.64, .01) | −.35 (−.64, −.06)* | .03 (−.33, .39) | −.38 (−.62, −.13)** | .07 (−.28, .42) | −.16 (−.45, .14) |
| Language | −.20 (−.52, .13) | −.39 (−.62, −.16)** | −.20 (−.53, .13) | −.32 (−.62, −.03)* | −.02 (−.38, .33) | −.43 (−.37, −.18)** | .00 (−.35, .36) | −.23 (−.53, .07) |
| Visuospatial | −.14 (−.45, .17) | −.28 (−.52, −.04)* | −.17 (−.48, .14) | −.37 (−.67, −.07)* | .23 (−.10, .56) | −.23 (−.49, .03) | .26 (−.08, .59) | .00 (−.31, .31) |
Other model covariates: age, sex, total intracranial volume, scanner type
Other model covariates: age, sex, education
p<.05
p<.01